Ladies who freeze their eggs at 40 have very restricted possibilities of having a profitable being pregnant, in line with a brand new examine by Imperial Faculty researchers. The examine suggests as an alternative that girls who wish to freeze their eggs for later being pregnant ought to achieve this earlier than the age of 36 as a approach of mitigating age-fertility decline and attaining a profitable livebirth.
A lady could resolve to freeze eggs for various causes. If there’s a medical concern, equivalent to chemotherapy, egg freezing allows being pregnant at a later time when she is healthier. Extra ladies are additionally selecting egg freezing for social causes. Some simply aren’t prepared for teenagers proper now. Freezing eggs permits ladies to pursue different commitments, equivalent to their profession, till they really feel able to have children.
Egg freezing, often known as mature oocyte cryopreservation, has a number of steps, beginning with ovarian stimulation. This includes taking artificial hormones to stimulate the ovaries to supply a number of eggs – as an alternative of the only egg that sometimes develops month-to-month. The eggs are then retrieved by way of transvaginal ultrasound aspiration.
As soon as the unfertilized eggs are harvested, they’re cooled to subzero temperatures to protect them for future use. That is completed by way of a course of referred to as vitrification – utilizing substances that stop ice crystals from forming. Then, when the frozen eggs have to be used, they’re thawed, fertilized with sperm in a lab, and implanted into the uterus.
However timing issues lots for egg freezing. A earlier examine in 2015 discovered that the optimum age vary for this technique is between ages 30 and 34. In distinction, this new examine checked out what occurs when ladies return to make use of their eggs to be able to try being pregnant.
Age and egg freezing
The researchers labored with a cohort of 373 ladies from a fertility middle in London, finishing up simulation cycles. They discovered that no livebirths have been achieved in ladies that went by way of egg freezing after 40 years outdated. Compared, over 80% of all livebirths have been achieved in ladies who had frozen their eggs between 36 and 39.
Whereas the information is from a single fertility middle, ladies needs to be suggested concerning the poor outcomes when embarking on egg freezing above the age of 40, Jara Ben Nagi, examine creator, mentioned in a press release. Ladies needs to be inspired to make use of this technique a lot sooner than the proof suggests they’re at the moment doing, Ben Nagi added.
As a part of their examine, the researchers additionally did an economical evaluation and located that the optimum age to undergo an egg freezing course of is 35 years outdated – with the particular person assuming a likelihood of returning to cryopreserved oocytes (egg cells) of over 60% and the willingness to spend roughly $20,000 for every livebirth, they added.
“It’s important ladies have essentially the most correct estimate of their chance of future success, to be able to make knowledgeable decisions concerning variety of cycles and facilitate the administration of future expectations,” the researchers wrote within the examine. “It’s paramount ladies are conscious the chance of a livebirth can’t be assured.”
The examine was revealed within the journal Archives of Gynecology and Obstetrics.